PTCA.us – Angioplasty and stenting digest.

Local perivascular delivery of anti-restenotic agents from a drug-eluting poly(ε-caprolactone) stent cuff.

December 6, 2005   Categories: Blogroll  Posted by admin

Here, a perivascular cuff to induce restenosis was constructed of a poly(ε-caprolactone) (PCL) formulation suitable for the controlled delivery of drugs. Placing the PCL cuff around the femoral artery, in vivo, resulted in reproducible restenosis-like lesions containing predominantly smooth muscle-actin positive cells.

Keywords: Controlled drug release; Local delivery; Drug-eluting stents; Poly(ε-caprolactone); Restenosis; Animal model

Abstract